1-Benzyl 2-methyl (2S)-piperazine-1,2-dicarboxylate

1-Benzyl 2-methyl (2S)-piperazine-1,2-dicarboxylate - Names and Identifiers

Name	O1-benzyl O2-methyl (2S)-piperazine-1,2-dicarboxylate
Synonyms	Methyl (S)-1-N-Cbz-piperazine-2-carboxylate (S)-benzyl methyl piperazine-1,2-dicarboxylate 1-Benzyl2-methyl(S)-piperazine-1,2-dicarboxylate (S)-1-benzyl 2-methyl piperazine-1,2-dicarboxylate 1-Benzyl 2-methyl (2S)-piperazine-1,2-dicarboxylate (S)-1-N-Cbz-piperazine-2-carboxylic acid methylester O1-benzyl O2-methyl (2S)-piperazine-1,2-dicarboxylate (S)-1-N-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester (2S)-1,2-Piperazinedicarboxylic acid 2-methyl 1-(phenylmethyl) ester 1,2-Piperazinedicarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (2S)-
CAS	314741-63-4
InChI	InChI=1/C14H18N2O4/c1-19-13(17)12-9-15-7-8-16(12)14(18)20-10-11-5-3-2-4-6-11/h2-6,12,15H,7-10H2,1H3/t12-/m0/s1

1-Benzyl 2-methyl (2S)-piperazine-1,2-dicarboxylate - Physico-chemical Properties

Molecular Formula	C14H18N2O4
Molar Mass	278.3
Density	1.212
Boling Point	406.5°C at 760 mmHg
Flash Point	199.7°C
Vapor Presure	8.08E-07mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.537

1-Benzyl 2-methyl (2S)-piperazine-1,2-dicarboxylate - Introduction

O1-benzyl O2-methyl (2S)-piperazine-1,2-dicarboxylate is an organic compound containing a piperazine ring and a methyl formate group in its chemical structure. The following is an introduction to its nature, use, preparation and safety information:

Nature:
O1-benzyl O2-methyl (2S)-piperazine-1,2-dicarboxylate is a colorless to light yellow solid. It has low solubility at room temperature and is soluble in some organic solvents such as chloroform, dimethylformamide and dichloromethane. Its melting point is about 150-155 degrees Celsius.

Use:
O1-benzyl O2-methyl (2S)-piperazine-1,2-dicarboxylate is a commonly used organic synthesis intermediate. It is widely used in the field of drug synthesis, especially for the synthesis of anti-cancer drugs and depression drugs. It can also be used as a chiral inducer in the organic synthesis reaction to play the role of catalyst.

Method:
The preparation method of O1-benzyl O2-methyl (2S)-piperazine-1,2-dicarboxylate can adopt many different synthetic routes. One common method is to obtain the product by reacting piperazine with methyl formate. The reaction can be carried out under neutral or basic conditions and usually requires heating of the reaction. Some auxiliary reagents and solvents may be required during the preparation process.

Safety Information:
O1-benzyl O2-methyl (2S)-piperazine-1,2-dicarboxylate is relatively safe under general operating conditions. However, it is still an organic synthetic raw material and requires users to take appropriate protective measures. Avoid inhalation, contact with skin and eyes during operation. If contact or aspiration occurs, rinse immediately with water and seek medical help. At the same time, it should be stored in a dry, cool place, away from fire and oxidizing agents.

Last Update：2024-04-09 21:11:58